What is the Mprize?
The Mprize consists of two separate prize competitions, both of which are judged by our scientific advisory board:
In the competition for the Longevity Prize, money is awarded to the producer of the world's oldest-ever mouse. This is restricted to the species used in virtually all laboratory work, Mus musculus, but no other restrictions should be placed on the way in which the mouse's lifespan is extended, provided that the methods used maintain cognitive and physical wellbeing.
The amount won by a winner of the Longevity Prize is in proportion to the size of the fund at that time, but also in proportion to the margin by which the previous record is broken.
The Rejuvenation Prize rewards successful late-onset interventions performed on an aged mouse and has been instituted to satisfy two shortcomings of the Longevity Prize: first, it is of limited scientific value to focus on a single mouse (a statistical outlier); and second, it is very likely that interventions applied throughout life (as they are during Longevity Prize research) will always be ahead of those initiated late, and thus would have an ongoing advantage in a simple competition structure. Our most important end goal is not merely to extend life, but to promote the development of interventions that restore youthful physiology. By seeking interventions that are effective when initiated at a late age, this prize encourages scientific research that is most likely to benefit those reading these guidelines today.
The Rejuvenation Prize is not awarded for the life extension of an individual mouse but for a published, peer-reviewed study. The study must satisfy the following criteria:
The amount won by a successful new Rejuvenation Prize record is calculated in the same way as for the Longevity Prize, but is only awarded upon publication of the study in question.
Competitor Michal Masternak
My work expands on the work of Andrzej Bartke, the previous MPrize winner. The long life of his mouse resulted from "knocking out" the growth hormone receptor. We recognize that several types of dwarf mice have a longer lifespan than other mice. Our team will combine these two factors and breed mice lacking both growth hormone and growth hormone receptor.
We are breeding 80 extremely small mice, we expect them to be exceptionally long-lived but otherwise they are normal. Other groups of mice will be used to study insulin/glucose function to be able to correlate these changes with longevity outcome. A lack of insulin and/or trouble responding to insulin is a common health threat to overweight people. Additionally, people become insulin resistant and glucose intolerant as they age.