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Latest Mprize Winners
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Z Dave Sharp
On October 8, 2009 Dave Sharp, University of Texas, San Antonio was awarded the Special Mprize Lifespan Achievement. This special recognition was for the first pharmaceutical intervention to successfully extend the life of laboratory mice. The study, published in the journal Nature, showed that when aging mice were given the drug rapamycin, they lived longer than other mice. Read more about rapamycin in the news and the event. 
Andrzej Bartke
"...Dwarf mice...lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH), (and) live much longer than their normal siblings, and exhibit many symptoms of delayed aging." 
Steven Spindler
"Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, is a robust method of decelerating aging and the development of age-related diseases. The effects of CR are conserved in nearly every species tested, perhaps including humans. CR delays the onset and reduces the incidence and severity of age-related diseases, including cancer." |
Competitor Christian SellA decline in tissue function and protein synthesis occurs with increasing age. This catabolic state is associated with a decrease in the serum levels of IGF-I and IGF-I supplementation has been proposed as a therapy for elderly individuals. Not only is there a decline in the levels of IGF-I in the serum but the response of cells to IGF-I decreases with increasing age. In vitro, human cells that have reached the end of their lifespan do not proliferate in response to IGF-I or other growth factors that will induce proliferation in the cells early in their lifespan. The reason for this lack of response is not clear and may be tied to fundamental changes within the cell that are important to the loss of function seen in "old" cells. For example, the rate of protein synthesis is regulated in part by IGF-I and, as mentioned above, protein synthesis declines with age both in the body and in vitro. An understanding of the changes in IGF-I responses are regulated and their connection to the senescent growth arrest may provide novel therapeutic approaches to some of the problems associated with aging. 
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