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December 17, 2006

Obesity Avoidance vs. CR

Mary wrote an entry recently in which she wondered if we are biologically wired against CR.

Of course we are. Against real CR, that is.

I agree that we are culturally brainwashed to eat many unhealthy foods. Sure, our bodies are adapted to feast on and store fat and sugar when it is plentiful in order to save up for times of famine. But our obesogenic environment in which fat and sugar in huge amounts are constantly available, especially to the poorest of our citizens, is not natural. And in truth, it's not that hard to adapt to a diet that replaces unhealthy foods with healthy, lower calorie, higher nutrient foods. It's also not that hard, with with the right information and support, to adapt to a diet where you eat "80% full" as the Okinawans like to say, and you maintain a body weight that is unusually low for our overweight society.

But that's not CR. That's what most folks who are doing "moderate CR" are doing, and while there's not question that they will gain benefits in terms of lower risk of diseases, I seriously doubt that they are slowing their actual rate of biological aging by that much. A bit, yes, and every bit counts. But I strongly suspect that the calorie intake that most folks practicing moderate CR are enjoying is an obesity avoidance level, not CR in the lab animal sense of the word.

In the lab, they limit the diets of the control animals because they know that given unlimited access to food, all animals will eat themselves into pre-mature death. The controls are normal, "healthy" weights. People on moderate CR, the kind where they look younger than their overweight contemporaries and feel great and never really get hungry are probably closer to control group rats than to CR'd rats.

I bring this up because I've been re-evaluating my diet and lifestyle lately, largely in light of some spiritual growth brought on by the unpleasant media experiences of the last few months. I've been very happy in my CR journey so far, and I sure am a lot healthier at 102 pounds than I was at 137, or at 106 for that matter. But I'm starting to suspect that I'm really just at the low end of my obesity avoidance range, and that serious CR, the life-extending kind, for me, is a lower calorie level.

One can never be sure of course. There is no exact science that tells us what calorie level will yield what level of life-extension, and there are so many intervening factors that we just don't know. But I know that I'm not going even nearly as low as I could. I still have many days when I eat suboptimally, when I pig out in restaurants, when I have more wine than I need. None of this is consistent with my goals of living as long as possible as healthy as I can. Yet I've made a series of compromises to fit in, and to satisfy my own biological compulsions to eat more and store more calories.

It's so easy to let the biological rule the rational. Sometimes, that's a lot of fun... like when it's Sunday afternoon and you feel like mating. But it's not much fun when you're long term health is on the line, and I'm young enough to have a choice to make. If I go farther in my CR, now, I am probably young enough to benefit greatly. If I choose to remain a moderate, I will no doubt avoid early heart attack, diabetes, stroke, and maybe even cancer. But I won't look and feel forty at sixty.

I got into this to feel forty at sixty. The short term benefits are a tremendous blessing, but they're not nearly enough for me. And I have the tools (information) and the support (MR and a wonderful friend and family network) to go farther. I know what it's like to confront hunger when in calorie deficit, and I know it's not that big a deal. You just focus on the goal and enjoy your next meal even more than usual! Experienced CR practitioners tell me that once the initial weight loss is over and weight stabilizes at a consistent calorie level, the hunger goes away, except for right before a meal when we all enjoy feeling hungry in anticipation of a meal to be enjoyed. Consistency and getting the right nutrition becomes even more important than before, as getting good nutrition for the most part makes food cravings go away.

Obesity avoidance is great, and on a public health level, I'd love for everyone to convert to the kinds of habits that turned me from a 137 pound unhealthy person to a 104 pound bouncing bundle of happiness. It could save our health care system if more and more people were to change their diets in small, easy ways that result in big long term health improvements. I'm all for that. I can teach you how to do that. I can honestly say that it's not that hard. With the info and support, anyone can do it. Yes, it would be better if the environment were more supportive, and I pledge to do everything I can to improve it. But the individual can make changes, and I'm willing to help.

That kind of change isn't enough for me. I want to live as long as I can in a healthy body and mind, and as of now, CR is the only intervention that has a prayer of extending my healthspan. I no longer think that eating out a lot or fitting in with family or friends or satisfying a craving for gak are good reasons (for me) to compromise my health future.

So I'm thinking of going lower. A lot lower. And that will come with a price.

My averaging has worked really well when it was 1300 - 1400 and those 1000-1200 days were quickly balanced out by a big restaurant meal. But if I want to go lower, those restaurant meals need to be very few and very far between.

I look pretty darn normal now, just thin and younger than I am. But I might eventually actually get skinny. And if MR doesn't like it, I'll beat him with a steamed carrot!

When I was in calorie deficit for quite awhile last fall, I experienced hunger like I never had before. And it was weird, distracting. It took awhile to get used to focusing my brain in another direction. Yet at the same time, I found it brought things into perspective. I was less neurotic than usual. Things seemed less pressing. I thought to myself, as a co-worker brought a crisis to my office, "I'd love to join you in your hysteria, but I am too busy contemplating my next cup of cottage cheese to truly freak out about your so-called emergency."

It was a good thing. I had a greater sense of balance. I loved my food, loved my work, loved my family and friends, but felt an almost Zen-like calm. A calm that goes away at about 1350 calories a day.

I am thinking of going lower, and of leaving some familiar things behind. Like frequent lunches out. Like the ongoing protest, "But I'm a moderate! I'm normal! Look at me... I eat out!"

I want to live my life according to my own priorities and goals, my true will, if you will, not according to unconsidered and unquestioned biological compulsions, and not according to what will please others.

So I have some decisions to make. It's almost January, and it's a good time for change.

But right now it's bedtime, and I have to be out the door at 6:45 am, so enough change for tonight.

Posted by april at December 17, 2006 9:54 PM

Comments

In going lower, don't you forget that all the packaged and prepared food you'll it like those south beach diet things are not good for you, nor is the garlic powder or the eggwhites you buy prepared. Longevity is not all about restricting calories. It's also about eating free farmed stuff and exercising in fresh air.
No matter how low you go in calories, your eggwhites will still come from chicken farms loaded with hormones and toxins and those will get to you at some point in life.
I mean, you won't be able to live to be 120 in a western society living in a major city (don't forget all the other toxins you get while driving, while heating your house) even if you do strict CR, so why not go with the moderate and opt for a disease free 100?

Posted by: istanbulwitchy at December 17, 2006 8:12 PM

Also Aprilitamu, don't forget that you don't eat some very important foods; beans, wholegrains and fish. Those have very high nutritious values and your diet lacks them immensely. They are all protective of cancer. Don't rely on supplements, who knows what is really in them? So, in your quest to go even lower calories, just remember most of the time it counts more what you eat than where or how much you eat. If you don't eat legumes, wholegrains and fish regularly, your going lower will only mean malnutrition since you're so dependent on those eggwhites which god knows from how raised animals they come from.
you might easily get cancer while attempting strict cron if you don't eat what the longest living people of this earth have been eating for centuries.
Legumes, wholegrains and fish.

Posted by: istanbulwitchy at December 17, 2006 8:31 PM

quote: So I'm thinking of going lower. A lot lower. And that will come with a price.

yes, april, yes it will....

quote: I want to live my life according to my own priorities and goals, my true will, if you will, not according to unconsidered and unquestioned biological compulsions, and not according to what will please others.

that is the only way to go. It is so shit to deal with others and trying to please them, because they really don't have your best interests at heart,

I just feel that they need to see you fail to justify how badly they are treating their bodies.

cron people are out-numbered...we are alone.(thats how I feel sometimes)

April, for what its worth, I support/look forward to reading of this journey of yours.

Sheila

Posted by: sheila at December 17, 2006 8:46 PM

Hi April
I'll raise a glass of wine next time I have some with the family, to wish you well on the new weight goal journey. Thanks to you and Mary Robinson for reminding us about the empty calories in gak, specially during the holidays. I kept within my caloric level while eating some gak last week and feel worse for it now. I also relaxed my no-dairy rule, drank too much wine and got a sick stomach for a day after the holiday office lunch.

Like you, I've experienced a biological negative reaction when I reached 3 pounds below my current set point. I actually had to share with my fellow yoga practitioners one day that I thought I had overdone my caloric restriction, was starving and had to go home with apprehension about the weight, unable to practice. I guess I have made a committment to the yoga practice and it requires a certain level of caloric intake.

From what I have analyzed, I don't think I'm practicing moderate CR, but I'm not at extreme CR either. I'm somewhere in between, perhaps in your current situation.

Why don't you give MR for Xmas the gift of some salsa lessons in Philadelphia? You would probably both enjoy that and you've expressed wanting to be twirled dancing salsa.

Cheers
Arturo

Posted by: Arturo at December 17, 2006 9:42 PM

Hi April, I've been reading your interesting blogs. I'm new to this site and practice calorie resriction or limitation with adequate nurition. Well I'm trying to anyway. I have found the word "restriction" is taken by many people to be harsh, unfriendly and hardline. I sure don't like being percieved in such a political manner. In my experience I have found the name triggers defensiveness in people. I wish calorie restriction sounded more friendly. It would if they'd change the name. // I know you enjoy your dinners out but would also like to lower your cals. I find that drinking wine is an appeite stimulant and if i have it just before a meal i loosen up and let my guard down and eat too much. I don't find i want to drink it much anymore. If I do want it I will have it last of all. Then i don't have the calories to spare for it. Hooray! I didn't make room for and i didn't loose control.

Posted by: mamamia at December 18, 2006 4:42 AM

Hi April,

How low are you thinking of going? I've often wondered whether CR folks have come to any sort of consensus on how low is too low. Obviously, there is some level of restriction below which it is literally impossible to get all the nutrition you need. Has anyone figured that out? Are you planning on gradually lowering your target calorie intake or are you just going cold turkey?

I, too, have been thinking a lot about my goals for 2007. Now that I'm 40 pounds lighter, I'm turning my attention to exercise for cardiovascular and bone health. So my goal for 2007 is to come up with a simple, sustainable exercise program. It's strange - in the past, exercise was always about losing weight for me. Now that's not an issue anymore, I feel liberated to think about exercise in a whole new way. I think I used to see my half-hour on a treadmill as a punishment for being overweight. Now that my focus is on health, I find myself thinking of exercise as something that can actually be fun. And it certainly isn't quite so embarrassing to show up at a gym now that I'm thinner. (I used to feel like a beached whale in my gym clothes.)

Anyway, good luck with your goals. I'll be interested to hear how it goes.

To Mamamia: I think a lot of people find the term "caloric restriction" off-putting. In their book, Delaney and Walford suggested calling it the "longevity diet," which I sort of like. It puts all the emphasis on the real goal of CR - living longer. However, anything with the word "diet" is problematic. We live in a culture that is *so* jaded (and rightly so) when it comes to dieting that I think people would hear this term and think it's just another fad. So I don't know what the solution is.
When people ask me how I lost all my weight, I simply say: "I'm on the stop-eating-crap diet." That always gets a laugh.

Posted by: Robin at December 18, 2006 8:11 AM

Again, I am so provoked by your entries. It is that time of year to take stock and think about the immediate and the distant future. I had been thinking about moderate CR, as I would like to be in control of and aware of the nutrients that I am consuming. I am not making excuses, but it seems that such a drastic modification of my diet could be a difficult point for my relationship. However, it is my body, and I must make decisions that will produce a better life for me. Thanks for the inspiration.

Posted by: Gina at December 18, 2006 8:26 AM

Good luck April - if your new low is too low your body will tell you, and not with just a bit of hunger either. You know enough to trust your body rather than what other people are telling you.

Posted by: Brooke at December 18, 2006 8:53 AM

Hey there. I know you do not want to discuss or even mention the name of the book you are currently reading about child obesity and prevention. However, my sister is giving birth to her second child this week and I really would love to give her this book. She currently has a two year old that already loves McDonald's french fries. I do not want to be the one to personally inform her. I think it is best she get ahold of some solid data and make her own decisions. If you are willing, I would love to give her the book for Xmas. Thanks so much

Posted by: Carolyn at December 18, 2006 10:21 AM

oh, I must agree with Istanbulwitchy...

Lately, the only protein source I will now allow myself is from raw fish (sashimi) from sushi bars.

And that is it. I love getting my raw Omega 3's from the raw salmon that I eat.

I realize that fish has the potential of mercury poisoning, but I just outweigh the benefits.

Sheila

Posted by: sheila at December 18, 2006 10:11 PM

Shelia,

For people who are really on CR (and I get the sense that you are or are becoming one) salmon is not as good a choice as flax oil. Here's the short(ish) version of why:

Longer-lived and/or CR'd animals have less long chain omega threes in their mitochondrial membranes. They both convert less of the short omega threes into long omega threes, and they tend to incorporate less of the long ones into the mitochondrial membranes. However, when you feed them DHA and EPA (the long chain omega threes found in salmon) to them directly (as in feeding them salmon) it overrides their ability to minimize the long chain omega threes that make it into the mitochondrial membranes. Feeding the CR'd animals more DHA and EPA increases the rate of free radical damage to mitochondrial DNA. Since we're more like the CR'd animals, we want to avoid this. That's why flax oil (which has short chain omega threes) is a better choice for omega threes for us.

Also, salmon tastes like cat breath. :)
http://www.mprize.org/blogs/archives/2006/04/catbreath_fish.html

a

Posted by: April at December 19, 2006 6:15 AM

Z-mu, you know I love you, but you're wrong on every score. Extending maximum lifespan really can only be done by restricting calories. It's not what you eat, it's how much you eat, assuming that you do get adequate nutrition, which I do, as crunched on my software. And while you're right that South Beach Diet wraps (which I eat less than once a week as it is) are not a great CR food, eggwhites are. You just don't happen to like them. Check out organic Eggology eggwhites for an organic source (may be hard to find where you are, but you don't like eggwhites anyhow... for those who do, but are concerned about chemicals, they're the way to go and available at Whole Foods.)

I don't rely on supplements for nutrition... I get the RDA of everything but zinc from food. Very few people do that. Beans and whole grains are not necessary foods to get good nutrition. MR eats beans, but at my calorie level, they're just not a good buy. I eat them sometimes... had some chickpeas the other day... but one certainly doesn't require them. Grains are just unnecessary and for someone small on strict CR, a waste of calories. I do eat 5 calories a day of wheat bran (1 tablespoon) for extra fiber.

Don't rely on myths or "common sense" to find out what good nutrition or malnutrition is... do your diet on software. How are you liking CRON-O-Meter? I found it hard to use at first but got accustomed in a week or so. Going lower in calories means more strict attention to nutrition, but that doesn't mean eating relatively empty foods like grains. Quite the opposite, in fact.

You're quite right that pollution is a concern, which is yet another reason why we all have to work to get the Republicans kicked out of the White House in 2008.

Alas, I doubt that strict CR will get us to 120 (at least starting as late as I did) and I am fairly sure moderate CR won't get anyone to 100, unless one combines it with very lucky genes. That's why I support research into biotech that will eventually do a better job.

a

Posted by: April at December 19, 2006 6:23 AM

Carolyn... I'll tell you off blog!

:)

a

Posted by: April at December 19, 2006 6:30 AM

Hi April, good luck on taking CR lower i'm sure you'll do great! I'm sure you will make it to 120 :)

You said that people shouldn't consider CR until at least 21, I was 20 when I started =/

Heres a quote from an okinawa article:

"Ushi advises her 77 year old daughter, is moderation. If you want to grow old as I am you must eat less. Never stuff yourself! Listen to me "hara hachi bu". Ushi is 104 years old :)

I reckon strict CR will get us younger CRers somwhere between 110-120.

Posted by: matt - uk at December 19, 2006 6:52 AM

Sheila, you would have to be eating 340 gms or 12 ounces of raw salmon a day to get the recommended 70 gms of protein! Yikes! Consuming that much of any one meat or fish simply cannot (in my opinion) be either healthy or sensible, never mind thinking about the mercury levels. JD

Posted by: Judith at December 19, 2006 10:31 AM

Hi april,
Just wanted to quickly respond to you since you responded to me on Mary's blog.

I guess I really don't feel that you are extreme at all. I found all the fuss about your magazine articles pretty crazy. I think you've hit a good balance and done a great job with it and all that you do for all of us is just wonderful. (I'm a fan:) I've been to the extreme myself and it can get uncomfortable. I've done it with the raw food and that is truly extreme; to pull yourself right out of your social circle because of your food choices (or lack of them) is a little nuts to me. I ended up not much healthier and feeling a bit foolish for all that I put my family through for a year and a half. So any change these days for me must be done gently and carefully. That's why I'm loving the CR that I'm doing, cause it hasn't negatively impacted my family at all. It's all good truth be told.

Anyway, just thought I'd mention it. I'm glad for you with this choice and I'm glad you've got the support you need to make this work. Cheers

Deborah

Posted by: Deborah at December 19, 2006 1:07 PM

Judith, you are right, I do need to find better protein sources.

I just LOVE sashimi! I also eat the raw tuna and yellotail.

April, thanks for the info on flax versus salmon.

I will take that into consideration.

Sheila

Posted by: sheila at December 19, 2006 8:19 PM

Obviously we are not on the same score here. I don't think I am wrong since I am not making it up when I take food examples of the longest living peoples' diets which are legumes and grains.
To prove my point, please show me one person who lived longer than he/she is supposed to doing your style of or any kind of american designed style of cron. I can show you thousands of people who lived to be older than 100 doing what I advocate should be done: Eating organic pulses, legumes, veggies, brown rice and grains, lots of fish and non-cow's milk products, some lean meats. of course eating reasonable amounts of them, but eating them.
Eggwhites won't save you. every nutritional practioner will tell you that it's not healhty to count on them as your sole source of protein. There are so many more healthy options. Go out of your Americanized cronie mind and explore what the longest people on this earth have been doing.
Don't get offended please. I am only strongly suggesting that your way may not be the best way.

Posted by: istanbulwitchy at December 20, 2006 7:39 PM

In Okinawan which has the largest number of people aged 100 or above in the world, the elders who lived to 100 all had a BMI between 18-22, so presumably anybody below or above that range dropped dead before 100, so the type of CR that takes your BMI below 18 will I expect prevent you reaching 100 years of age. see Okinawa Program, page 48.

So what human evidence do we have that it is worth the risk ? Not even people who want radical life extension (Aubrey de grey and Ray kurzweil) practice anything beyond mild CR and they likely would do more serious CR if they thought it would extend their lives, I am sure they would be dedicated enough do follow a serious CR regime.

Posted by: Paul at December 24, 2006 6:00 PM

Hi Paul,

Thanks for your comment and welcome!

Unfortunately, your statement is an example of the wrong way to read evidence. I addressed that in great detail in a post that was probably before you started reading the blog. It's here:
http://www.mprize.org/blogs/archives/2006/11/a_caution_about.html

Also, Aubrey de Grey doesn't practice CR at all. He doesn't believe that any kind of CR will result in any more than a few years life-extension. Unless something has changed radically since I last saw him, his diet is an example of neither CR nor ON. He's naturally skinny, but that (as has been gone over many times) is not CR and does not confer life-extension benefits.

I believe that Ray's calculation about what level of CR to practice is largely influenced by his age when he started and his age now, but I haven't discussed it with him in detail. Ray is also the most optimistic of folks about the nearness of life-extending biotech, so that may influence his choices too. MR and I are hopeful but less optimistic.

The risks of serious CR can be managed with carefully tailored bone building and cardio exercise, careful nutrition and supplementation, and a warm jacket and scarf in winter. So for me, there's not much of a downside. For someone with different priorities, it wouldn't make sense. That's why I stress that these are very individual decisions. I'm just sharing my own throught process.

april

Posted by: April at December 27, 2006 2:29 PM

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